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差向異構(gòu)化是指在化學反應(yīng)中，一個差向異構(gòu)體（epimer）轉(zhuǎn)化為另一個差向異構(gòu)體或其手性對映體的過程。在肽合成中，氨基酸的差向異構(gòu)化是一個常見的副反應(yīng)，可能導致肽的整體構(gòu)象改變，從而影響其生物活性。差向異構(gòu)化產(chǎn)物與目標肽在物理特性上高度相似，增加了純化的難度。在多肽合成及多肽藥物...
Thepharmaceuticalindustryiscontinuallysearchingtoautomatetechniquesforrapidoptimizationorlibraryproduction.Theautomationofhydrogenationisoneofthoseprocessesthatisdrawinghighinterestduetoitsfrequencyindrugsynthesis.OfficialThalesNanowebsite:...
查看詳情ThehydrogenationofaseriesoffunctionalgroupshasbeenperformedusingH-Cube®,anovelcontinuous-flowmicrofluidichydrogenationreactor.TheseexperimentsdemonstratethattheH-Cube®canperformadiverserangeofheterogeneoushydrogenationreactionswithh...
查看詳情INTRODUCTIONSelectivecatalytichydrogenationofa-b-unsaturatedaldehydesisanimportantstepintheindustrialpreparationoffinechemicalsａndattractsmuchinterestforfundamentalresearchincatalysis1.Cinnamylalcoholplaysanimportantroleintheperfumeａndflavo...
查看詳情TheH-CubePro™improvesupontheoriginalH-Cube®byofferinggreaterhydrogenproduction（upto60mL/min）forhigherthroughput,widertemperaturerange（from10-150°C）including-forthefirsttime-activecoolingformoreselectivereactions.Importantly,reacta...
查看詳情TheX-Cube™isacontinuousflowreactor,capableofperformingchemicalreactionunderinertconditions,temperaturesupto200°Cａndpressuresupto150bar.Thispapershowsthatcarbon-carbonformingreactionsarefarmoreefficientontheX-Cube™incomparisontob...
查看詳情Metalcontaminationisamajorprolemforthepharmaceuticalａndfinechemicalindustries.Alargeamountoftimeａndresourceisspentpurifyingcompoundsaftercatalyticsteps,sothatthematalcancentrationinwithintheacceptablelimit.Generally,theacceptablelimitis0.05...
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